Role of vascular endothelial growth factor in regulation of physiological angiogenesis.

By N. Ferrara. American Journal of Physiology - Cell Physiology, 2001

1,071 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0446386093f3bd21a26d02c3fc9a8494cf97d6d5

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Citations in the corpus

Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. (2016, background): “Stimulation with VEGF results in various distinct responses in endothelial cells, including proliferation, migration, differentiation, and survival [83].”
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 (2003, neutral): “Whereas the RTK Flk1 binds only VEGF, the RTK Flt1 binds both VEGF and PG”
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death (2003, background): “Considering the complexity of the transcriptional and translational regulation of VEGF expressio”
Angiogenesis in rheumatoid arthritis (2002, background): “VEGF exerts its effects through tyrosine kinase receptors Flt-1 (fms-like tyrosine kinase receptor; also known as VEGF-R1) and Flk-1/KDR (fetal liver kinase receptor/kinase-insert-domain-containing receptor; also known as VEGF-R2) [17,18].”
VEGF as a Key Mediator of Angiogenesis in Cancer (2005, background): “VEGF is a homodimeric glycoprotein with a molecular weight of approximately 45 kDa. At least four main VEGF isoforms exist as a result of alternative patterns of splicing. These isoforms are 121, 165, 189 and 206 amino acids long, with the 165-amino acid form representing the predominant species of ”
Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. (2008, background): “Germline SNPs were logical candidates to study because angiogenesis is largely a host-mediated event, as opposed to a process mediated by somatic mutations in the tumor.(22,23) This is critical in that these changes are not controlled by the tumor, but instead are an inherited predictive factor.”
Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix (2003, background): “Several additional VEGF family proteins have been identified recently, including VEGF-B, VEGF-C, VEGF-D, and VEGF-E (for a review, see Ferrara, 2001), but their specific function in wound angiogenesis remains unclear.”
Annexin 1: a new paracrine agent secreted by a novel mechanism (2002, neutral): “Angiogenesis is regulated by a variety of growth factors and inhibitors, mainly of the vascular endothelial growth factor (VEGF), angiopoietin (Ang) and ephrin (Eph) families (Ferrara, 2001).”
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 (2002, background): “gif" NDATA ITEM> ]> Vascular endothelial growth factor (VEGF) and its receptor tyrosine kinase-2 (VEGFR-2 or Flk1/KDR) have received much attention for therapeutic stimulation or inhibition of angiogenesi”
Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “Several molecules have been implicated, but members of the VEGF family of growth factors (VEGF, VEGF-B, -C, -D, and PlGF) and their receptors (VEGFR-1, -2, and -3) play critical roles in mediating angiogenic processes (Carmeliet, 2000; Carmeliet et al., 2001; Dvorak, 2000; Ferrara, 2001; Karkkainen ”
Vascular endothelial growth factor in eye disease. (2008, background): “The action of VEGF in stimulating angiogenesis is well established (Ferrara, 1999; Ferrara, 2001).”