Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

By M. Autiero, J. Waltenberger, D. Communi, A. Kranz, L. Moons, D. Lambrechts, J. Kroll, S. Plaisance, M. D. Mol, F. Bono and 18 more. Nature Medicine, 2003

813 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7528d88537874fcd584860bccab2a6e257cbcf86

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Citations in the corpus

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate (2008, background): “PlGF is a major member of the VEGF family, which is a ligand for VEGFR-1 that enhances the angiogenic response of VEGF [61,62].”
Signal transduction by vascular endothelial growth factor receptors. (2012, background): “Inhibition of angiogenesis, immune cell recruitment, fatty acid uptake KID Y801 Y830 Y833 Y853 Y1230 Y1231 Y1337 Y1169 EC-proliferation, 3D-organization of EC Regulation of 1054/1059 phosphorylation LymphEC-migration, -survival LymphEC-proliferation, -migration, -survival LymphEC-proliferation, -mig”
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. (2007, background): “First, PlGF stimulates EC growth and migration (Autiero et al., 2003; Carmeliet et al., 2001), mobilizes angiocompetent bone marrow progenitors (Hattori et al., 2002; Kaplan et al., 2005), and acts as a survival factor for existing vessels.”
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. (2005, background): “Furthermore, Flt-1 alone can bind two additional VEGF homologues, PlGF and VEGF-B, and the former has been shown, under experimental in vitro conditions, to induce differential signaling through Flt-1 when compared with VEGF itself (37).”
Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. (2018, background): “To conclude, VEGFR-1 activation by binding PlGF induces the indirect activation of VEGFR-2 [38, 78].”
Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “found hat human VEGF-165 stimulates Tyr1213 phosphorylation hereas human PlGF-152 stimulates only Tyr1309 phoshorylation as determined by mass spectrometry in cells xpressing only mouse VEGFR1 receptors [122].”