Targeted destabilization of HY5 during light-regulated development of Arabidopsis

By M. Osterlund, C. Hardtke, N. Wei, X. Deng. Nature, 2000

1,294 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/040515a51f9337b76d57b7e239d67d16568e057c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Goldberg
2. M. Estelle
3. C. Fankhauser
4. Aaron Ciechanover
5. X. Deng
6. K. Folta
7. Yuling Jiao
8. O. Lau

In Plant Science

1. C. Fankhauser
2. M. Estelle
3. X. Deng
4. Sofia D Carvalho
5. K. Folta
6. Yuling Jiao
7. O. Lau
8. E. Schäfer

Citations in the corpus

• Phytochrome‐mediated photoperception and signal transduction in higher plants (2002, background): “This suggests that COP1 could negatively regulate photomorphogenesis by mediating the polyubiquitination of HY5, thus marking it for subsequent degradation by the proteasome (Osterlund et al., 2000).”
• Light-dependent regulation of carotenoid biosynthesis in plants (2009, background): “…the UV-damaged DNA binding protein 1 (DDB1) and the de-etiolated-1 (DET1) factor, interact with COP1 and other proteins from the signalosome complex, leading to ubiquitination of transcription factors (Osterlund et al., 2000; Schroeder et al., 2002; Chen et al., 2004; Yanawaga et al., 2004).”
• A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase (2007, background): “For example, COP1 has both a RING-type domain in the N terminus and a WD-40 repeat domain in the C terminus that can bind several protein targets, including HY5, thereby recruiting an E2 and targeting HY5 and other substrates for ubiquitination and degradation by the proteasom”
• The Ubiquitin-Proteasome Pathway and Plant Development (2004, background): “Because aMAP kinase cascade has been implicated in ethylene signaling (Novikova et al., 2000; Ouaked et al., 2003), it will be interesting to see if phosphorylation of EIN3 is required for its stabilization.”
• Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. (2003, neutral): “(Osterlund et al., 2000”
• The ubiquitin–26S proteasome system at the nexus of plant biology (2009, background): “Particularly important to photomorphogenesis is the RING E3 COP1, the dark-dependent translocation of which into the nucleus has been implicated in the turnover of a number of photomorphogenic effectors, including the transcription factor LONG-HYPOCOTYL 5 (HY5”
• Light signal transduction in higher plants. (2004, background): “Similarly, the light-hyposensitive phenotype of hy5 mutants can also be reconciled with this model (77, 142, 161).”
• Photoreceptors and Control of Horticultural Plant Traits (2015, background): “Phytochromes control gene expression, at least in part, by negatively regulating the repression imparted by the COP/DET/FUS proteins, leading to accumulation of transcriptional activators such as HY5, HYH, LAF1, and HFR1 (Duek et al., 2004; Osterlund et al., 2000; Zhu et al., 2008).”
• Analysis of Transcription Factor HY5 Genomic Binding Sites Revealed Its Hierarchical Role in Light Regulation of Development[W] (2007, methodology): “…light-to-dark transition, we first checked the protein levels of HA:HY5 and endogenous HY5 in the transgenic line and the wild type, respectively, grown for 4 d under white light and then trans- ferred to darkness, because HY5 protein is known to be degraded in the dark (Osterlund et al., 2000).”
• Auxin cross-talk: integration of signalling pathways to control plant development. (2002, background): “The C-terminal domain of COP1 has been demonstrated to interact with HY5 (Osterlund et al., 2000) and can repress photomorphogenesis (Oyama et al.”
• Characterization of OsbZIP23 as a Key Player of the Basic Leucine Zipper Transcription Factor Family for Conferring Abscisic Acid Sensitivity and Salinity and Drought Tolerance in Rice1[W][OA] (2008, background): “Among those are HY5, which mediates plant light response (Chattopadhyay et al., 1998; Osterlund et al., 2000), ATB2, which is involved in Suc-specific sugar sensing and signaling (Rook et al., 1998), and AtbZIP60, which regulates the endoplasmic reticulum stress response in amanner unique to plants…”
• HFR1 encodes an atypical bHLH protein that acts in phytochrome A signal transduction (2000, background): “Genetic and molecular approaches have identified a significant number of components that potentially function as signaling intermediates and have provided evidence of both shared and separate pathway branches for individual phytochrome family members (Soh et al. 1998; Bolle et al. 2000; Büche et al.”