qnr Prevalence in Ceftazidime-Resistant Enterobacteriaceae Isolates from the United States

By Ari Robicsek, J. Strahilevitz, D. Sahm, G. Jacoby, D. Hooper. Antimicrobial Agents and Chemotherapy, 2006

626 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0388ba8d90d67ec22b34cc45a60cb37553b8099a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. L. Poirel
2. P. Nordmann
3. G. Jacoby
4. K. Bush
5. J. Pitout
6. P. Bradford
7. F. Codjoe
8. E. Donkor

In Molecular Medicine

1. L. Poirel
2. P. Nordmann
3. G. Jacoby
4. D. Hooper
5. Ari Robicsek
6. J. Strahilevitz
7. K. Bush
8. P. Bradford

In Pharmacology

1. D. Hooper
2. Ari Robicsek
3. G. Jacoby
4. P. Nordmann
5. L. Poirel
6. J. Strahilevitz

Citations in the corpus

• Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. (2007, methodology): “The qnrB-like gene from E. cloacae K34 isolate was qnrB2 (445/445 bp), which was mostly identified from the QnrB-positive enterobacterial isolates from the USA.4 The qnrB-like genes from E. cloacae K37 and C. freundii K70 isolates coded for proteins showing 97% and 96% amino acid identity with QnrB1”
• Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme (2006, methodology): “The three known qnr genes, qnrA, qnrB (6), and qnrS (3), and their variants have widely penetrated clinical isolates of Enterobacteriaceae from the United States and are present in a substantial minority of ceftazidime-resistant organisms (10).”
• Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat (2009, methodology): “-Lactamase genes associated with qnrB2 include CMY-1 (138), CTX-M-14 (223), CTX-M-15 (113, 158), IMP-4 (60), IMP-8 (218), KPC-2 (40), and SHV-12 (91); qnrB3 has been reported only from the United States (166), but qnrB4 has a worldwide distribution and a strong linkage with the gene for the AmpC-typ”
• Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms (2009, background): “These three proteins are required for induction of the ampC gene in both Enterobacteriaceae and P. aeruginosa, although there is no direct evidence linking AmpG to the ampC induction pathway of P. aeruginosa (11, 81, 88, 109, 110, 127, 138, 139).”