Prevalence in the United States of aac(6′)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme

By Chinsu Park, Ari Robicsek, G. Jacoby, D. Sahm, D. Hooper. Antimicrobial Agents and Chemotherapy, 2006

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Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms (2009, background): “These three proteins are required for induction of the ampC gene in both Enterobacteriaceae and P. aeruginosa, although there is no direct evidence linking AmpG to the ampC induction pathway of P. aeruginosa (11, 81, 88, 109, 110, 127, 138, 139).”
Acquired Antibiotic Resistance Genes: An Overview (2011, background): “These substitutions are responsible for the enzyme’s ability to acetylate ciprofloxacin (Park et al., 2006; Robicsek et al., 2006b; Strahilevitz et al., 2009).”
Nanotechnology as a therapeutic tool to combat microbial resistance. (2013, background): “This new gene codes for an N-acetyltransferse that acetylates an NH2 group of the fluoroquinolone molecule, thereby inactivating it [2,35,36].”