Imaging Intracellular Fluorescent Proteins at Nanometer Resolution

By Eric Betzig, Georges H. Patterson, Rachid Sougrat, O. W. Lindwasser, S. Olenych, J. Bonifacino, Michael W. Davidson, Jennifer Lippincott-Schwartz, H. Hess. Science, 2006

8,413 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biophysics, Structural Biology

View Paper: https://www.semanticscholar.org/paper/036ec5ab6c4ff8b0ac4b0a596a46e4dbea39ee46

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Citations in the corpus

Whole cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution (2008, neutral): “The other approach is based on single-molecule localization of photoswitchable fluorophores, a method independently reported under different names including stochastic optical reconstruction microscopy (STORM)4, (fluorescence) photoactivation localization microscopy ((f)PALM)5,6 and other variants7.”
Ultrasound Localization Microscopy and Super-Resolution: A State of the Art (2018, neutral): “In PALM (photoactivated localization microscopy [63],à), FPALM (fluorescence photoactivation localization microscopy[72]) or STORM (stochastic optical reconstruction microscopy [73]), fluorescent labels switch between bright and dark states, making it such that only a subset of them are observable i”
Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, neutral): “The development of super-resolution light microcopy, photo-activated localization microscopy (PALM), and stochastic optical reconstruction microscopy (STORM) (12, 67, 122) is based on the use of photo-switchable fluorescent probes to resolve multiple molecules located within a diffraction-limited sp”
In situ transcription profiling of single cells reveals spatial organization of cells in the mouse hippocampus (2016, neutral): “, Lubeck et al. devised a general method to highly multiplex single molecule in situ mRNA imaging irrespective of transcript density using super-resolution microscopy (Betzig et al., 2006; Rust et al., 2006; Lubeck and Cai, 2012;).”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, neutral): “These techniques are now being extended to achieve superresolution level imaging (141, 917).”
Photoactivatable mCherry for high-resolution two-color fluorescence microscopy (2009, neutral): “PAFPs and photoswitchable dyes also provide probes necessary for high-resolution optical techniques, such as photoactivated localization microscopy (PALM”