Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

By Jae-Eun Kang, M. Lim, Randall J. Bateman, James J. Lee, L. Smyth, John R. Cirrito, N. Fujiki, S. Nishino, D. Holtzman. Science, 2009

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Amyloid-β Induced Neuronal Dysfunction in Alzheimer’s Disease: From Synapses toward Neural Networks (2010, background): “, as well as during normal physiological processes, such as the sleep–wake cycl”
β-Amyloid accumulation in the human brain after one night of sleep deprivation (2018, background): “In rodents, chronic sleep restriction led to increases in ISF Aβ levels (4) and in a Drosophila model of Alzheimer’s disease (AD), chronic sleep deprivation (SD) resulted in higher Aβ accumulation (5).”
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. (2012, background): “2005), as well as during normal physiological processes, such as the sleep–wake cycle (Kang et al. 2009).”
Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease (2012, background): “Finally, known risk factors for AD such as genetic profile, age, vascular damage, or common comorbidities like sleep disorders and epilepsy, all predispose to excessive activity and a subsequent burden on metabolism and plasticity [17,18,66–68].”