Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus

By J. Stevens, A. Corper, C. Basler, J. Taubenberger, P. Palese, Ian A. Wilson. 2004

508 citations recorded by the source corpus.

How researchers see this paper

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Influenza: lessons from past pandemics, warnings from current incidents (2005, background): “The three-dimensional structure of the HA of the 1918 virus indicates that, despite retaining the residues in the host-receptor-binding site that are characteristic of an avian precursor H”
New Vaccine Design and Delivery Technologies (2019, background): “This is usually performed using protein complexes with symmetries matching that of the antigen, and can range from small scaffolds such as the foldon trimerization domain from T4 fibritin [22, 23] to larger multimers such as ferritin [24] that display multiple copies of the oligomeric antigen.”
Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain (2010, background): “1) (15), we predicted that replacement of the intervening loop with a short linker peptide would not disrupt the folding of the remainder of the molecule.”
New World Bats Harbor Diverse Influenza A Viruses (2013, background): “The H18 HA ectodomain was expressed in the HA0 form [13] .”