Chemistry and biochemistry of oxidative stress in neurodegenerative disease.

By L. Sayre, M. Smith, George Perry. Current Medicinal Chemistry, 2001

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“Sleeping Beauty”: Quiescence in Saccharomyces cerevisiae (2004, background): “ease (133), and loss-of-function mutations in DJ-1, a protein”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, positive): “As OS appears to be a common underlying factor in the various adverse conditions characterized by SNV (Sayre et al., 2001; Valko et al., 2007), the study of SNV to OS might improve our understanding of how this particular form of cell stress causes selective neuronal losses in brain, as well as reve”
8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis (2009, background): “As a result of these studies 8-OHdG has been established as an important biomarker of oxidative stress (12, 27), of cancer risk to humans by mechanisms of oxygen-free radicals (28, 29), of aging processes including degenerative diseases (30, 31), and in general as a biological marker of lifestyle an”
Metals, oxidative stress and neurodegenerative disorders (2010, neutral): “Besides accumulation of Ab and increased inflammatory markers, neurofibrillary tangles represent one of the pathologic hallmarks of the AD brain composed primarily of an aberrant form of the tau protein, a highly soluble microtubule-associated protein [4].”