Fasting, circadian rhythms, and time restricted feeding in healthy lifespan
By V. Longo, Satchidananda Panda. Cell Metabolism, 2016
841 citations recorded by the source corpus.
Summary Feeding in most animals is confined to a defined period, leaving short periods of fasting that coincide with sleep. Fasting enables organisms to enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which feeding time is restricted to certain hours of the day, allows the daily fasting period to last >12 h, thus imparting pleiotropic benefits in multiple organisms. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMD, both basic science and translational research are warranted to develop fasting-associated interventions into effective and inexpensive treatments with the potential to improve healthspan.
Subfields: Endocrine and Autonomic Systems, Physiology
View Paper: https://www.semanticscholar.org/paper/02e6c4d94ba215b701144490ff826bcc5cc4b843
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In Endocrine and Autonomic Systems
In Physiology
- John C. Newman
- Claudio Franceschi
- E. Verdin
- Mark P. Mattson
- Paolo Garagnani
- M. Capri
- S. Salvioli
- C. Leeuwenburgh
Citations in the corpus
- Impact of intermittent fasting on health and disease processes (2016, neutral): “The role of PF and FMDs in cancer prevention and treatment has been discussed in more detail elsewhere (Longo and Mattson, 2014; Longo and Panda, 2016).”
- Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting (2017, background): “In contrast to traditional caloric restriction paradigms, IF is a dietary approach that requires fasting for varying periods of time, typically for 12 hours or longer (6,10,11).”
- Inflammaging and 'Garb-aging'. (2017, background): “Accordingly, long-term moderate caloric restriction [31] but also time-restricted feeding, in which food consumption is restricted to certain hours of the day, or fasting-mimicking diets appear the most promising to provide pleiotropic benefits against inflammation [32].”
- β-Hydroxybutyrate (2017, positive): “The effects of such regimens on invertebrate, rodent, and human health have been reviewed and can include extended longevity, cognitive protections, reductions in cancer, and immune rejuvenation (75, 82).”