The role of presenilin cofactors in the γ-secretase complex

By N. Takasugi, T. Tomita, I. Hayashi, Makiko Tsuruoka, Manabu Niimura, Yasuko Takahashi, G. Thinakaran, T. Iwatsubo. Nature, 2003

822 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/02a1badef9d75f7e6075630bbc0f598344307049

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In Molecular Biology

1. M. Fortini
2. Yue Hu
3. D. Selkoe
4. David Watson
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In Physiology

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Citations in the corpus

• Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease (2018, background): “C83 and C99 are further cleaved at the γ-sites by γ-secretase complex, which includes presenilin-1, nicastrin, Aph-1 and Pen2 (Capell et al., 1998; De Strooper et al., 1998; Yu et al., 2000; Francis et al., 2002; Goutte et al., 2002; Takasugi et al., 2003).”
• Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates (2003, neutral): “The interaction of Aph1 and Pen-2 with both immature PS1 (PS1 holoprotein) and PS1 CTF suggests that Aph1 and Pen-2 also play a role in the stabilization of FL PS1 or its endoproteolysis, as suggested by recent reports (Luo et al., 2003; Takasugi et al., 2003).”
• Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases (2004, background): “, and γ-secretase, an unusual intramembrane aspartyl protease containing presenilin at its catalytic site complexed with three other membrane proteins, nicastrin, Aph-1 and Pen-2 (ref”
• Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “Aph-1 aids the formation of a precomplex, which interacts with PS1 or PS2 while Pen-2 enters the complex to initiate the cleavage of PS1 or PS2 to form an N-terminal 28-kDa fragment and a C-terminal 18-kDa fragment, both of which are critical to the γ-secretase complex (Takasugi et al. 2003).”
• Different cofactor activities in γ-secretase assembly (2003, background): “Our results are consistent with recent works showing that Aph-1 acts early during -secretase assembly in the initial stabilization of Psn holoprotein, and that Pen-2 is required for holoprotein endoproteolysis (Gu et al., 2003; Luo et al., 2003; Takasugi et al., 2003).”