Adult rat and human bone marrow stromal cells differentiate into neurons

By D. Woodbury, E. Schwarz, D. Prockop, I. Black. Journal of Neuroscience Research, 2000

2,543 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/027546b6b57539e737e1efad70e26eb2b788cd3d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. S. Shi
2. A. Caplan
3. S. Gronthos

In Genetics

1. A. Caplan
2. S. Shi
3. S. Gronthos
4. P. Robey
5. P. Bianco
6. G. T. Huang
7. L. Meirelles
8. Nance B. Nardi

In Pulmonary and Respiratory Medicine

1. A. Caplan

Citations in the corpus

• Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. (2007, background): “demonstrated the differentiation of rat and human bone marrow stromal cells into neurons [14] in 2000.”
• Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. (2002, background): “Two recent reports have shown that human MSCs could differentiate in vitro into neurons (49, 57) and astrocytes (49).”
• Isolation of multipotent adult stem cells from the dermis of mammalian skin (2001, background): “and are not easily induced to produce neural protein”
• Plasticity of marrow-derived stem cells. (2003, neutral): “These neuronal cells express neuron-specific antigens, but assessment of electrophysiological (functional) characteristics has not yet been demonstrated.(50)”
• Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. (2002, background): “Bone marrow-derived MSCs(3) are precursors with high proliferative capacity (3) and can differentiate into adipocytes, chondrocytes, osteoblasts (4), and possibly other cell types (5).”
• Autologous mesenchymal stem cell transplantation in stroke patients (2005, background): “15 It is still controversial, however, whether spon-taneous cell fusion 18,19 or true differentiation 20,21 was the primary cause for these unexpected cell outcomes.”
• Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow (2003, methodology): “…adipose and other tissues have been demonstrated to have the potential to differentiate into cells with characteristics of neurons, oligodendrocytes, and astrocytes [Kopen et al., 1999; Brazelton et al., 2000; Sanchez-Ramos et al., 2000; Woodbury et al., 2000; Deng et al., 2001; Toma et al., 2001].”
• Mesenchymal stem cells: clinical applications and biological characterization. (2004, background): “Treatment of rat cells with DMSO/butylated hydroxyanisole in the presence of bFGF and PDGF was also successful in inducing a neural phenotype ( Woodbury et al., 2000, 2002 ).”