A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy.

By K. B. Johnsen, J. M. Gudbergsson, M. N. Skov, L. Pilgaard, T. Moos, M. Duroux. Biochimica et Biophysica Acta, 2014

684 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/02726aef883ed43bbb6b587f80413cbaa9de2ca7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. E. Batrakova
2. Raghu Kalluri
3. C. Théry
4. Richard J. Simpson
5. H. Ji
6. M. Wood
7. S. El Andaloussi
8. Dihua Yu

In Molecular Biology

1. Raghu Kalluri
2. E. Batrakova
3. C. Théry
4. Richard J. Simpson
5. M. Wood
6. P. Vader
7. H. Ji
8. Jan Lötvall

Citations in the corpus

• Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods (2015, background): “Furthermore, the therapeutic use of EVs has been investigated in a growing number of publications [11].”
• Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “Drugs that could particularly benefit from delivery by EVs are small RNA therapeutics, including miRNAs and siRNAs, and anti-inflammatory agents as well as anti-cancer drugs (219).”
• Exosomes in cancer development, metastasis, and immunity (2019, background): “Therefore, exosomes have become a promising tool for delivery and transfer of drugs, miRNAs, small-interfering RNAs (siRNAs), short hairpin RNAs (shRNAs), and other compounds that remain stable in exosomes for the treatment of cancer and other diseases [153].”
• The biology and function of exosomes in cancer. (2016, background): “The utility of exosomes as naturally derived delivery vehicles for therapeutic agents is being actively explored (98).”
• Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “In this respect, several reports indicated that exosomes may have an immune privileged status that can efficiently decrease drug clearance [20-22].”
• Lipids in exosomes: Current knowledge and the way forward. (2017, neutral): “We refer to recent reviews regarding strategies and the present status of the field [9,11,89-92].”
• Development of Exosome-encapsulated Paclitaxel to Overcome MDR in Cancer cells (2015, neutral): “Recently, exosomes have begun to be explored for use as drug delivery vehicles for nucleic acids (14-19), gene delivery (20), and small molecule drugs, such as curcumin (12, 21, 22), and doxorubicin (23).”
• Bovine milk-derived exosomes for drug delivery (2015, background): “Secreted membrane vesicles such as exosomes inherently possess many characteristics of a drug delivery vehicle and could be accepted in clinics [30].”
• The Smart Drug Delivery System and Its Clinical Potential (2016, background): “For example, exosomes can be directed to specific tissues, while maintaining their biological functions [174-178].”
• A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. (2015, background): “Exosomes are important regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest their importance for diagnostic and therapeutic applications, and as drug delivery vehicles [16].”