Classifying collective cancer cell invasion

By Peter Friedl, J. Locker, Erik Sahai, J. Segall. Nature Cell Biology, 2012

931 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/026bd433cc3756438f54f7f8b8e49612cbd83020

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Citations in the corpus

EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “…groups of cells, which is commonly seen at the borders of invasive carcinomas, is best documented in the case of carcinomas of the breast and lungs (Friedl et al., 2012); similar invasive cohorts undoubtedly participate in invasion by other types of carcinoma cells as well (Chung et al., 2016;…”
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters (2016, background): “However, they leave unresolved two important questions: how do tumor cell clusters emerge from the primary tumor, and which molecular features identify cell clusters that metastasize? An important clinical observation is that cancer cells invade the surrounding stroma as cohesive clusters in the maj”
EMT, MET, plasticity and tumor metastasis (2020, background): “An important counter-model to EMT is “clustered migration”, or “collective invasion” [62].”
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “These advantages can be utilized by carcinomas during invasion and intravasation of multicellular strands (101).”
Rho GTPase signalling in cell migration (2015, background): “Cells can migrate as single cells or collectively as groups [4].”
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “Although invasion is commonly conceptualized as a single-cell process, the majority of solid tumors display features of collective invasion in which cells invade cohesively as a multicellular unit (Friedl et al., 2012; Leighton et al., 1960).”
Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “Indeed, this type of “collective migration” might be even more common than single-cell dissemination, as supported by several studies using lineage tracing approaches and detection of clustered tumor cells in circulation (Friedl et al , 2012; Aceto et al , 2014; Cheung et al , 2016).”
EMT subtype influences epithelial plasticity and mode of cell migration (2018, background): “Two distinct patterns of invasive growth leading to metastases have been described: single cell migration leading to dissemination of individual tumor cells, and collective (group) migration resulting in multi-cellular circulating tumor cell (CTC) clusters (Cheung and Ewald, 2016; Friedl et al., 201”