Pax7 is required for the specification of myogenic satellite cells.

By P. Seale, L. Sabourin, A. Girgis-Gabardo, A. Mansouri, P. Gruss, Michael A. Rudnicki. Cell, 2000

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View Paper: https://www.semanticscholar.org/paper/01fec805559fd0d392bf92d52288661d4e6ce9a7

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Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “In skeletal muscle, satellite cells specifically express the Pax7 gene, which is essential for their maintenance in the perinatal (Kuang et al., 2006; Oustanina et al., 2004; Relaix et al., 2006; Seale et al., 2000), but not adult (Lepper et al.”
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle (2011, background): “Unfortunately, the Pax7-null mouse is not a good model for determining the necessity of satellite cells in muscle growth in the adult because of severe maturation problems and high mortality (<10% survive to adulthood) (Oustanina et al., 2004; Seale et al., 2000).”
Transcriptional regulation of erythropoiesis: an affair involving multiple partners (2002, background): “…muscle cells from mice containing homozygous disruption of the muscle-speci®c Pax 7 gene produced about a 10-fold increase in the number of hematopoietic colonies compared to cells from wildtype mice suggesting that Pax 7 may normally repress the hematopoietic lineage (Seale et al., 2000).”
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. (2004, background): “…of satellite cells was accompanied by reduction of Pax7, a specific marker of quiescent and activated satellite cells that is rapidly down-regulated upon myogenic differentiation (Seale et al. 2000), and activation of muscle creatine kinase (MCK) and myosin heavy chain (MHC) gene expression (Fig.”
Myostatin negatively regulates satellite cell activation and self-renewal (2003, background): “Further, immunostaining with antibodies against Pax7 (satellite cell marker) on serial sections established that the cells positive for Myostatin immunoreactivity are indeed the satellite cells (Seale et al., 2000) (Fig.”
Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, background): “muscle may contribute to the hematopoietic system [16–18].”
Satellite Cells and Skeletal Muscle Regeneration (2015, positive): “The discovery of myogenic regulatory factors (MRFs) and paired box proteins then allowed to further characterize myogenic cell behavior during the different steps of myogenesis (102,120,198,269,316).”
Myogenic satellite cells: physiology to molecular biology. (2001, background): “Recent work from the Rudnicki laboratory (169) identified the paired box transcription factor, Pax7, expressed selectively in quiescent and proliferating satellite cells.”
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells (2006, background): “Satellite cells were not observed in the mutant, leading to the proposal that Pax7 is essential for the specification of adult muscle progenitor cells (Seale et al., 2000).”
Enhancement of meat production by environmental manipulations in embryo and young broilers (2006, background): “Pax7 is selectively expressed in quiescent and proliferating satellite cells in rodents (Seale et al., 2000) and chicks (Halevy et al., 2004), and is probably required for their self-renewal (Olguin and Olwin, 2004; Oustanina et al., 2004; Zammit et al., 2004).”
Building muscle: molecular regulation of myogenesis. (2012, background): “Constitutive Pax7 knockout mice present a loss of satellite cells that manifests after birth (Seale et al. 2000).”
Satellite cells and the muscle stem cell niche. (2013, background): “These CD45 muscle SP cells persist in Pax7 / germline null mice and can efficiently differentiate into hematopoietic cells in culture (24, 478).”
Myogenic specification of side population cells in skeletal muscle (2002, background): “Importantly, Pax7 -deficient muscle entirely lacks myogenic satellite cells, yet contains muscle SP cells that exhibit a high level of hematopoietic progenitor activity (Seale et al., 2000).”