Cellular metabolism and disease: what do metabolic outliers teach us?
By Ralph J. Deberardinis, Craig B. Thompson. Cell, 2012
798 citations recorded by the source corpus.
An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human diseases involve abnormal metabolic states – often genetically programmed – that perturb normal physiology and lead to severe tissue dysfunction. Understanding these metabolic outliers is now a crucial frontier in disease-oriented research. This review discusses the broad impact of metabolism in cellular function, how modern concepts of metabolism can inform our understanding of common diseases like cancer, and considers the prospects of developing new metabolic approaches to disease treatment.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/01bec33c6230e7101520cc9891caf83557721bea
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Huafeng Zhang
- Navdeep S. Chandel
- Ralph J. Deberardinis
- Ping Gao
- T. Walther
- Robert V Farese
- Linchong Sun
- A. Schulze
In Physiology
- T. Walther
- Robert V Farese
- Ping Gao
- R. Zechner
- Huafeng Zhang
- Linchong Sun
- Navdeep S. Chandel
- Ralph J. Deberardinis
Citations in the corpus
- Fundamentals of cancer metabolism (2016, background): “alteredmetabolic fluxesmay ormay not cause changes inmetabolite levels (186).”
- Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Metabolic reprogramming is one of the major features of cancer, during which characteristics of metabolic enzymes, upstream regulating molecules and downstream metabolic products, known as metabolites, are altered (DeBerardinis et al., 2008b; Heiden et al., 2009; Jones and Thompson, 2009; Hanahan an”
- Molecular mechanisms of diabetic kidney disease. (2014, neutral): “For example, many of the chromatin-modifying enzymes use adducts from intermediate metabolic products as cofactors (51, 52).”
- Cellular Fatty Acid Metabolism and Cancer (2013, background): “Lipidmetabolism is also altered in rapidly proliferating cells (for general reviews, see Swinnen et al., 2006; DeBerardinis and Thompson, 2012; Santos and Schulze, 2012).”