RAS is regulated by the let-7 microRNA family.

By Steven M. Johnson, H. Grosshans, Jaclyn Shingara, M. Byrom, R. Jarvis, Angie Cheng, E. Labourier, Kristy L. Reinert, D. Brown, Frank J. Slack. Cell, 2005

3,774 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/01ae7d930255dd36a3308bd912d29d79859934db

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Carlo Maria Croce
2. George A. Calin
3. David P. Bartel
4. Manel Esteller
5. Joshua T. Mendell
6. Scott M. Hammond
7. Frank J. Slack
8. Phillip A. Sharp

In Molecular Biology

1. Carlo Maria Croce
2. George A. Calin
3. Manel Esteller
4. David P. Bartel
5. Scott M. Hammond
6. Joshua T. Mendell
7. John S. Mattick
8. Phillip A. Sharp

Citations in the corpus

• MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. (2008, methodology): “Target genes prediction of the differentially expressed miRNAs The analysis of miRNA predicted targets was determined using the algorithms of TargetScan 4.0 (Iizuka et al. 2003), PicTar (Roberts and Gores 2005), miRBase (Griffiths-Jones et al. 2006), and miRanda (Lagos-Quintana et al. 2001).”
• The essence of senescence. (2010, background): “For instance, increased expression of activated RAS genes is a common feature of human tumors (Elenbaas et al. 2001; Johnson et al. 2005; Okamura et al. 2006; Chen et al. 2009) that can be associated with the conversion from benign to malignant tumors (Quintanilla et al.”
• TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “By targeting multiple oncogenes such as RAS, HMGA2, and c-MYC, let-7 also functions as a tumor suppressor, most prominently in lung cancer (Johnson et al., 2005; Lee and Dutta, 2007; Mayr et al., 2007; Sampson et al., 2007).”
• The evolution of gene regulation by transcription factors and microRNAs (2007, background): “There are two cases, namely let-7:lin-41 and let-7:let-60–RAS, in which the target relationship has been experimentally dissected in C. elegans, and for which there is evidence for conservation in mammals that was obtained from computational target predictions and reciprocal expression patterns of t”
• Extensive post-transcriptional regulation of microRNAs and its implications for cancer. (2006, background): “The oncogene Ras is a validated target of Let-7 (Johnson et al. 2005).”