Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

By D. Jarrossay, G. Napolitani, M. Colonna, F. Sallusto, A. Lanzavecchia. European Journal of Immunology, 2001

911 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0179a88fb9b4193f9df651c047f398a33a08fa69

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TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. (2003, background): “In con- range of pattern recognition receptors that respond to distinct microbial products (Jarrossay et al., 2001; Kado-trast, transfer of CCR2 / PBMC had no effect on bacte- rial growth in the spleens of recipient mice.”
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, neutral): “Among TLRs that recognize nucleic acids and are involved in the immune response to viruses (TLR3, TLR7, TLR8, and TLR9), monocytes weakly express TLR3 and TLR9 and do not respond to TLR3 and TLR9 agonists (Jarrossay et al., 2001; Kadowaki et al., 2001) (Figure S3).”
The perfect mix: recent progress in adjuvant research (2007, background): “TLRs are expressed on the surface or in the endosomes of different APC subtype”
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function (2003, background): “Triggering of TLR on DCs induces the release of cytokines and the up-regulation of accessory molecules for efficient stimulation of T lymphocytes (35, 36) and DC maturation by LPS is mediated through TLR4, which generates intracellular signaling most notably via the transcription factor NF- B (37).”
Toll-like receptors. (2003, background): “In humans TOLL-LIKE RECEPTORS 359 MDCs produce IL-12 in response to a variety of stimuli including LPS, whereas PDCs preferentially produce IFN-α upon viral infection and in response to CpG DNA (121, 275).”
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “This may reflect the specialization of PDCs to recognize distinct TLR ligands (39, 40), as well as their extraordinary ability to produce large amounts of IFN- , because of a prolonged endosomal retention of TLR ligands with consequent sustained MyD88/IRF-7 signaling (53).”
Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “Thus, Poly IC and TLR7-TLR8, which induce an optimal cytokine milieu (IL-12 and type I IFN-a) and are able to directly activate DC subsets specialized for CD4 activation and cross-presentation, offer great promise as adjuvants (Figure 1).”