Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis.

By Z. Y. Wang, T. Nakano, Joshua M. Gendron, Junxian He, Meng Chen, Dionne Vafeados, Yanli Yang, S. Fujioka, S. Yoshida, T. Asami and 1 more. Developmental Cell, 2002

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Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-1D suppresses BR-deficient and BR-insensitive (bri1) phenotypes and enhances feedback inhibition of BR biosynthesis. BZR1 protein accumulates in the nucleus of elongating cells of dark-grown hypocotyls and is stabilized by BR signaling and the bzr1-1D mutation. Our results demonstrate that BZR1 is a positive regulator of the BR signaling pathway that mediates both downstream BR responses and feedback regulation of BR biosynthesis.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/015c68fa57485058bd9cb1663b1c0a365aad884e

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Citations in the corpus

Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis (2010, positive): “Activation of either BZR1 or BZR2/BES1 by dominant mutations (bzr1-1D, bes1-D, and bzr1-S173A) suppresses nearly all phenotypes of the BR-insensitive bri1 and bin2 mutants (Wang et al., 2002; Yin et al., 2002).”
The Regulation of Brassinosteroid Biosynthesis in Arabidopsis (2013, background): “BZR1 plays a key role, not only as a transcriptional inducer, but also as a repressor (He et al., 2005; Wang et al., 2002).”
BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation. (2002, neutral): “…nuclear Microarray Analysisaccumulation is regulated by GSK-3 in complex with Ten-day-old seedlings of wild-type (Col), bes1-D (a recapitulation the scaffolding proteins axin and APC (Huelsken and transgenic line showing similar phenotypes to the bes1-D mutant, Birchmeier, 2001; Woodgett, 2001).”
Brassinosteroid signal transduction from cell surface receptor kinases to nuclear transcription factors (2009, background): “, and BZR1 and BZR2, which directly bind to DNA and regulate BR-responsive gene expressio”
Brassinosteroid signal transduction from receptor kinases to transcription factors. (2010, background): “BES1 is 89% identical to BZR1 and was also named BZR2 (93).”
Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses[OPEN] (2019, background): “BES1, BZR1, and the homologs BEH1-BEH4 are atypical basic helix–loop–helix (bHLH) TFs that function redundantly as master regulators of BR-responsive gene expression (Wang et al., 2002; Yin et al., 2002, 2005; Chen et al., 2019a).”
The AtGenExpress hormone and chemical treatment data set: experimental design, data evaluation, model data analysis and data access. (2008, background): “The BR biosynthetic genes At5g05690/CPD (Szekeres et al. , 1996), At3g50660/DWF4 (Choe et al. , 1998) and At3g30180/BR6ox2 (Kim et al. , 2005; Nomura et al. , 2005), and the BR signaling components, At3g61460/BRH1 (Molnar et al. , 2002) and At4g36780 [a homolog of BZR1 (Wang et al. , 2002)], are clu”
A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana. (2011, background): “They are unique to plants and share high homology at the amino acid level (Wang et al., 2002; Yin et al., 2002; Zhao et al., 2002).”
Growth-defense tradeoffs in plants: a balancing act to optimize fitness. (2014, neutral): “In the absence of BR, the glycogen-synthase-kinase-3-like kinase BRASSINOSTEROID INSENSITIVE 2 (BIN2) phosphorylates two nuclear-localized transcription factors, BRI1-EMS-SUPPRESSOR 1 (BES1) and BRASSINAZOLE-RESISTANT 1 (BZR1), to block activation of BR-responsive genes (He et al., 2002; Wang et al.”