NF-κB: a key role in inflammatory diseases

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MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits. (2005, background): “Activation of receptors triggers major intracellular signalling pathways: mitogenactivated protein kinase (MAPK) pathways [26–29], and the pathway leading to activation of the transcription factor nuclear factor kappa B (NF nB) [26,30].”
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? (2016, neutral): “There are no competing interests to declare.”
Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “IKK-mediated phosphorylation of IκB is a significant step in NF-κB activation [75].”
Inflammation, a Key Event in Cancer Development (2006, background): “NF-nB Mediate inflammation progress, promoting chronic inflammation (134, 135, 142) Promote the production of mutagenic reactive oxygen species (128) Protect transformed cells from apoptosis (157, 158) Promote tumor invasion and metastasis (5, 160) Feedback loop between proinflammatory cytokines (13”