Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.

By Jose A. Obeso, C. Olanow, M. Rodríguez-Oroz, P. Krack, R. Kumar, A. Lang. New England Journal of Medicine, 2001

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Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. (2004, background): “Moreover, DBS of the subthalamic nucleus (STN) or globus pallidus internus (GPi) has largely replaced pallidotomy in the treatment of the cardinal motor features of Parkinson’s disease (PD) (resting tremor, rigidity, bradykinesia) (Obeso et al., 2001).”
Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. (2004, background): “Three main targets have been identified that when ablated or stimulated result in beneficial clinical effects: the ventralis intermedius of the thalamus, the globus pallidus internus, and the subthalamic nucleus (Benabid et al. 1996; Gross and Lozano 2000; Obeso et al. 2001).”
Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation. (2006, background): “In current clinical practice, the STN is the target of choice for DBS treatment of PD, even though GPi DBS is similarly effective (Burchiel et al. 1999; Obeso et al. 2001; Rodriguez- Oroz et al. 2005).”
Patient-specific analysis of the volume of tissue activated during deep brain stimulation (2007, background): “Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson's disease (PD) (Obeso et al., 2001), essential tremor (Benabid et al., 1996), and dystonia (Vidailhet et al., 2005).”