From charcot to lou gehrig: deciphering selective motor neuron death in als

By D. Cleveland, Jeffrey D. Rothstein. Nature Reviews Neuroscience, 2001

1,411 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/0077c01b8ffa8b585f4e9b05bbb2cf3cf37b77bd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. T. Miller
2. A. Sheldon
3. A. Hall
4. Peter Carmeliet
5. B. Bean
6. Jeffrey D. Rothstein
7. M. Robinson
8. A. Schmidt

In Genetics

1. Robert H. Brown
2. J. Shorter
3. Aaron Gitler
4. Oliver D. King
5. Peter Carmeliet
6. Jeffrey D. Rothstein
7. Clifford J. Woolf
8. Berislav Zlokovic

In Neurology

1. Oliver D. King
2. Robert H. Brown
3. J. Shorter
4. Aaron Gitler
5. Jeffrey D. Rothstein
6. Clifford J. Woolf
7. Berislav Zlokovic
8. R. Parker

Citations in the corpus

• TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration (2009, background): “By contrast, ALS presents with muscle weakness and spasticity due to degeneration of motor neurons in both layer 5 of cortex and in the spinal cord, resulting in death from respiratory failure in 3–5 years (2, 3).”
• The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. (2007, background): “It is characterized by a progressive loss of motor neurons and is generally fatal within 1–5 years of onset (for review, see Cleveland and Rothstein, 2001).”
• Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. (2004, background): “The cause of ALS is unknown with the exception of rare familial forms, particularly those associated with mutations of the superoxide dismutase-1 gene (Al-Chalabi and Leigh, 2000; Cleveland and Rothstein, 2001).”
• Current hypotheses for the underlying biology of amyotrophic lateral sclerosis (2009, background): “Clearance of glutamate from the synaptic cleft by glutamate transporters is critical in preventing repetitive firing and subsequent excitotoxicity.(1) In motor neurons, rapid removal of synaptic glutamate is accomplished primarily by the astrocytic glutamate transporter EAAT2.”
• Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. (2002, background): “Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by chronic and selective degeneration of motor neurons in the brain and spinal cord (Cleveland and Rothstein 2001).”
• Stress granules as crucibles of ALS pathogenesis (2013, background): “TDP-43 and FUS: an emerging role for RNA-binding proteins in neurodegenerative disease ALS is a fairly common neurodegenerative disease caused by a selective loss of motor neurons from the brain and spinal cord (Cleveland and Rothstein, 2001).”
• VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model (2004, background): “and because SOD1 G93A mice develop severe motor neuron degeneration closely resembling the human disease, they represent the best available animal model for AL”
• Intrinsic Membrane Hyperexcitability of ALS Patient-Derived Motor Neurons (2014, background): “The excitotoxicity neurodegeneration hypothesis posits that excessive glutamatergic synaptic activity in ALS leads to calcium overload and cell death (Cleveland and Rothstein, 2001; Pasinelli and Brown, 2006).”