Precise genome modification in the crop species Zea mays using zinc-finger nucleases

By V. Shukla, Y. Doyon, Jeffrey C. Miller, Russell Dekelver, E. A. Moehle, Sarah E. Worden, Jon C. Mitchell, Nicole L. Arnold, Sunita M. Gopalan, Xiangdong Meng and 15 more. Nature, 2009

914 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/0067e855be25f9e314c73d384de0abc24ed759cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Carroll
2. Kabin Xie
3. A. Klug
4. Daniel F. Voytas
5. Yinong Yang
6. M. Holmes
7. F. Urnov
8. P. Gregory

In Plant Science

1. Kabin Xie
2. D. Carroll
3. Daniel F. Voytas
4. Yinong Yang
5. J. Keith Joung
6. Jeffry D. Sander

Citations in the corpus

• RNA-guided genome editing in plants using a CRISPR-Cas system. (2013, methodology): “Both ZFN and TALEN have been used in plant gene targeting and genome editing (Shukla et  al., 2009; Townsend et  al., 2009; Mahfouz et  al., 2011; Weinthal et al., 2013; Zhang et al., 2013).”
• TALENs: a widely applicable technology for targeted genome editing (2012, neutral): “…38 , catfish 39 , sea urchin 40 , frog 41 , pig 42 , cattle 43 , cricket 8 , rabbit 44 , silkworm 45 , butterfly 46 , mouse 47, 48 , rat 49, 50 , soybean 51, 52 , thale cress 53, 54 , corn 55 , tobacco 56 , petunia 57 , hamster cells 58 , and human somatic 59, 60 and pluripotent stem cells 61–63 .”
• Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA[OPEN] (2015, background): “As a result, reports describing successful gene editing or site-specific trait gene integration through HDR in plants are limited (Cai et al., 2009; Shukla et al., 2009; Townsend et al., 2009; Ainley et al., 2013; D’Halluin et al., 2013; Li et al., 2013; Shan et al., 2013; Zhang et al., 2013).”
• The discovery of zinc fingers and their applications in gene regulation and genome manipulation. (2010, background): “recent paper in Nature on genome modification in maize (54) was accompanied by a paper from another group on tobacco (55).”
• Genome Engineering of Crops with Designer Nucleases (2012, methodology): “Another example of gene editing using ZFNs was published by Shukla et al. (2009). h e authors generated ZFNs that targeted the maize IPK1 gene encoding the inositol-1,3,4,5,6-pentakisphosphate enzyme. h is enzyme is an important catalyst in the phytate biosynthesis pathway, contributing to…”
• Genome Editing of Plants (2017, methodology): “…targeted DSBs using designed SSNs other factors such as donor construct design, DNA delivery method, genomic target accessibility, and DNA repair status all appear to be important (Britt and May, 2003; D’Halluin et al., 2008; Kumar and Fladung, 2001; Shukla et al., 2009; Svitatshev et al., 2015).”
• A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity (2011, background): “Accordingly, designer nuclease-based genome engineering has been successfully established in more than 10 model organisms thus far, including plants (3,4), invertebrates (5), fish (6,7) and mammals (8).”