Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

By M. Asahi, Xiaoying Wang, Tatsuro Mori, T. Sumii, Jae‐Chang Jung, M. A. Moskowitz, M. E. Fini, E. H. Lo. Journal of Neuroscience, 2001

1,007 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0044ee3e913f9d142c7b434567f0d673ee375736

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. E. Van den Steen
2. G. Opdenakker
3. S. Doré
4. T. Mabuchi
5. G. D. del Zoppo
6. Gary A. Rosenberg
7. G. Moalem-Taylor
8. P. Austin

In Epidemiology

1. Berislav Zlokovic
2. C. Iadecola

In Molecular Biology

1. E. Candelario-Jalil
2. Gary A. Rosenberg
3. T. Mabuchi
4. G. Opdenakker
5. S. Doré
6. P. E. Van den Steen
7. G. D. del Zoppo

Citations in the corpus

• The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “6) [12,127 – 129].”
• Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. (2019, background): “Tight junctions between adjacent endothelial cells are formed by the transmembrane proteins occludin, claudins, and junctional adhesion molecule-1, as well as other accessory cytosolic proteins such ZO-1, cingulin, AF6, and 7H6 (Fig.”
• Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat (2007, background): “Zona occludens protein was shown to be degraded in ischemic injury in the mouse brain, but occludin was found to be unaffected (Asahi et al, 2001).”
• Matrix metalloproteinases in neuroinflammation (2002, background): “A MMP-9 knockout mouse was found to have reduced infarct size and less BBB damage (Asahi et al., 2000, 2001).”
• Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9) (2002, background): “Previously we discussed that myelin basic protein is a substrate of gelatinase B (Proost et al., 1993), and in the ischemia study also less myelin degradation was observed in the knockout mice (Asahi et al., 2001b).”
• Cerebral Microvessel Responses to Focal Ischemia (2003, background): “…have confirmed that pro-MMP-9, but not pro-MMP-2, expression is associated with focal ischemia in the rodent (Asahi et al., 2000, 2001a,b), and that deletion of the MMP-9 gene is associated with a decrease in microvascular permeability, but not in laminin immunoreactivity (Asahi et al., 2001b).”