Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes

By Robert M. Waterhouse, Evgenia V. Kriventseva, S. Meister, Z. Xi, Kanwal S. Alvarez, L. Bartholomay, C. Barillas-Mury, Guowu Bian, S. Blandin, B. Christensen and 25 more. Science, 2007

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Phenoloxidase: a key component of the insect immune system (2012, background): “One possibility is that a higher number of pathogen species may lead to increased specialization, via a higher gene number in host species (Waterhouse et al., 2007).”
Global spread and persistence of dengue. (2008, background): “Comparative genomics analyses are also now possible with sequenced Drosophila melanogaster and Anopheles gambiae genomes (148).”
OrthoDB v10: sampling the diversity of animal, plant, fungal, protist, bacterial and viral genomes for evolutionary and functional annotations of orthologs (2018, methodology): “…benchmarks of the underlying algorithm (15,16), the accuracy of our methodology earned its reputation through many comparative genomic studies (e.g. 17– 19) , particularly in the OrthoDB provides tentative functional annotations of groups of orthologs and mapping to functional categories by…”
The Aedes aegypti Toll Pathway Controls Dengue Virus Infection (2008, methodology): “Toll and Imd signaling pathways were built on the basis of a recent bioinformatics prediction [17] with GeneMAPP2 software [39].”