Preventing complications of central venous catheterization.

By D. C. McGee, M. Gould. New England Journal of Medicine, 2003

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Simulation‐based mastery learning reduces complications during central venous catheter insertion in a medical intensive care unit * (2009, methodology): “4% described in other published reports (4, 18), is a particularly encouraging finding.”
The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit (2005, background): “Local signs suggestive of CRI include, in increasing order of specificity, erythema or induration extending 2 cm of the catheter exit site, cellulitis along the subcutaneous tract of the catheter, and pus at the catheter entry site.”
Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients (2006, methodology): “The ultrasound method is technically demanding, requiring well-trained operators and adequate experience in performing it [18].”
International evidence-based recommendations on ultrasound-guided vascular access (2012, background): “Although these procedures can have major and minor complications, their success significantly depends on patient anatomy, comorbid conditions and operator skill [1, 2].”