Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

By S. Takamori, J. Rhee, Christian Rosenmund, R. Jahn. Nature, 2000

880 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/ffcfce369b5c069104941aee3a94d626fc58e4ae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Cellular and Molecular Neuroscience

Citations in the corpus

Glutamate as a neurotransmitter in the healthy brain (2014, background): “There are three different isoforms: VGLUT1 (Slc17a7; Ni et al. 1994; Bellocchio et al. 1998, 2000; Takamori et al. 2000), VGLUT2 (Slc17a6; DNPI; Aihara et al.”
A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons (2002, background): “If this is the case, then cholinergic and serotoninergic terminals have the potential to store, and thus to release (Takamori et al., 2000, 2001), glutamate in addition to acetylcholine or serotonin.”
A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells (2010, methodology): “We found a reduction in the density of VGLUT1 puncta from RTT-iPSCs clones carrying 3 different MeCP2 mutations compared to HUES6 and distinct WT-iPSCs-derived Map2positive neurons, suggesting a specific defect in glutamate transport in RTT cultures (Figure 4B and Figure S4B).”
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis (2003, neutral): “To validate these findings with an independent method, we labelled brainstem sections with antibodies to vesicular glutamate and GABA (γ-aminobutyric acid) transporter”
From glutamate co-release to vesicular synergy: vesicular glutamate transporters (2011, background): “b | For 5-HT neurons, terminals that contain only VGLUT3 and that only release glutamate (1), terminals expressing VMAT2 and 5-HT transporter (SERT) (2), terminals with synaptic vesicles that contain both VMAT2 and VGLUT3, in addition to the plasma membrane transporter SERT (3) and terminals with sy”
The Existence of a Second Vesicular Glutamate Transporter Specifies Subpopulations of Glutamatergic Neurons (2001, background): “Second, VGLUT2 mediates a glutamate uptake activity that is very similar, if not identical, to the activity of native synaptic vesicles or recombinant VGLUT1 (Bellocchio et al., 2000; Takamori et al., 2000).”
Molecular anatomy of a trafficking organelle. (2006, background): “Analysis of glutamatergic and GABAergic vesicle subpopulations revealed no difference with respect to more than a dozen major vesicle proteins (Takamori et al., 2000a, 2000b).”
The synaptic vesicle cycle. (2004, neutral): “When VGlut1 was transfected into GABAergic neurons, their synapses became glutamatergic, in addition to remaining GABAergic (Takamori et al. 2000).”
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. (2004, background): “30 Takamori, S. et al. (2000) Identification of a vesicular glutamate”