Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

By Y. Kulathu, D. Komander. Nature reviews. Molecular cell biology, 2012

671 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ff9a095245b1816ea66eec594eb58916eebf440e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Steven P. Gygi
2. Mark P. Jedrychowski
3. S. Beausoleil
4. J. Harper
5. Wenyi Wei
6. Lei Chen
7. J. Wells
8. B. Schulman

In Oncology

1. J. Harper
2. Steven P. Gygi

Citations in the corpus

• Quantitative proteomics reveal a feed-forward model for mitochondrial PARKIN translocation and UB chain synthesis (2014, positive): “…by PINK1 dramatically activates its UB ligase activity and synthesis of K6, K11, K48, and K63 chain linkage types, providing, to our knowledge, the first example of a RING-HECT hybrid E3 that can intrinsically produce four specific linkage types (Kulathu and Komander, 2012; Ye and Rape, 2009).”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “For example, the mixed K11 and K63 linkages participate in the Epsin1-mediated endocytosis of major histocompatibility complex I (MHCI).(51,56)”