Importin α‐regulated nucleation of microtubules by TPX2

By C. Schatz, Rachel Santarella, A. Hoenger, E. Karsenti, I. Mattaj, O. Gruss, Rafael Edgardo Carazo-Salas. 2003

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Microtubule nucleation: γ-tubulin and beyond (2006, result): “This hypothesis is supported by the finding that certain mutations in -tubulin or Dgrip75 affect some but not all MTs in Drosophila oocytes (Schnorrer et al., 2002).”
Importin α mRNAs have distinct expression profiles during spermatogenesis (2006, background): “…2, in addition to its role in nuclear import, can inhibit mitotic spindle formation by binding to TPX2, an assembly factor (Gruss et al., 2001; Schatz et al., 2003), and the C. elegans germ-line-specific importin , IMA-2, has been shown to participate in nuclear envelope assembly (Geles et…”