Microtubule nucleation: γ-tubulin and beyond
By C. Wiese, Yixian Zheng. Journal of Cell Science, 2006
190 citations recorded by the source corpus.
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of microtubules. Recent work has improved our understanding of the molecular mechanisms of MT formation. In particular, it has shown that γ-tubulin and its associated proteins play key roles in microtubule nucleation and spindle assembly in evolutionarily distant species ranging from fungi to mammals. Other work indicates that γ-tubulin-mediated microtubule nucleation, although necessary, is not sufficient for mitotic spindle assembly but requires additional proteins that regulate microtubule nucleation independently of centrosomes.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2ee74070370b6dda40ef67015c682d8342c2d6a1
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
Citations in the corpus
- Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The role of γ-tubulin in the nucleation of MT filaments has been known for quite some time [2247, 2248, 2249].”