Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.

By Yuxiang Sun, Pei Wang, Hui Zheng, Roy G. Smith. Proceedings of the National Academy of Sciences of the United States of America, 2004

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Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “In these mice, global deletion of GHSR results in a lean phenotype and altered orexigenic and GHsecretory responses to administration of ghrelin (Sun et al., 2004).”
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “Moreover, Ghsr -null mice have a normal appetite, show a normal body size, body composition, body weight and bone density, and show normal serum leptin and insulin responses to fasting (124).”
Ghrelin: structure and function. (2005, background): “Mice lacking GHS-R (Ghsr-null mice) do not show the typical increases in GH release and food intake upon ghrelin administration, indicating that GHS-R is indeed the primary biologically relevant ghrelin receptor (228).”
The Hormonal Control of Food Intake (2007, neutral): “GHSR knockout animals were also only modestly lean (Sun et al., 2004).”
The Human Obesity Gene Map: The 2005 Update (2006, background): “31 GHSR Growth hormone (GH) secretagogue receptor Decreased BW (393)”