Filamins as integrators of cell mechanics and signalling

By T. Stossel, J. Condeelis, L. Cooley, J. Hartwig, A. Noegel, M. Schleicher, S. Shapiro. Nature reviews. Molecular cell biology, 2001

1,038 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cell migration in the forebrain. (2003, background): “FLNA crosslinks F-actin into orthogonal arrays, increasing the viscosity of the F-actin network and enhancing cell motility (Stossel et al. 2001).”
Trekking across the brain: the journey of neuronal migration. (2007, positive): “Filamin 1 is able to interact with a diverse group of transmembrane proteins and serves as a scaffold for signaling proteins of the Rho family of GTPases, which are also implicated in neurite extension and neuronal migration (Dhavan and Tsai, 2001; Luo, 2000; Stossel et al., 2001).”
Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “An identifying property of each crosslinking protein is the distance by which it bridges two actin filaments (FIGURE 3, B AND C); crosslink distances range from 10 nm for fimbrin to 160 nm for filamin (153, 282, 297).”
Furin at the cutting edge: From protein traffic to embryogenesis and disease (2002, background): “cgi?Q=Filamin%20not%20TRIM*%20%20not%20KIAA0317%20%20not%20MGC5302%20%20not%20FLJ13181&ORG=Hs">filamin , a subcortical actin-binding protein that is involved in cell locomotion and signallin”