Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

By A. Rostami-Hodjegan, G. Tucker. Nature reviews. Drug discovery, 2007

539 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Pharmacology, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/febb53ab2da57fe9d114bb8d7dd94cbd71e7a324

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In Pharmacology

1. Amin Rostami-Hodjegan
2. Masoud Jamei
3. G. Dickinson

Citations in the corpus

• A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates. (2009, background): “…effects of variable plasma proteins in different individuals (e.g. various pathophysiological conditions that influence the plasma proteins) [Step 3] must separate the protein binding affinity (a purer characteristic of the drug binding than fu) from the `system-related' value of protein…”