Diabetes and Cancer

By Edward L. Giovannucci, David M. Harlan, Michael C. Archer, R. Bergenstal, S. Gapstur, Laurel A. Habel, Michael Pollak, Judith G. Regensteiner, D. Yee. Diabetes Care, 2010

1,959 citations recorded by the source corpus.

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments. This consensus statement of experts assembled jointly by the American Diabetes Association and the American Cancer Society reviews the state of science concerning 1) the association between diabetes and cancer incidence or prognosis, 2) risk factors common to both diabetes and cancer, 3) possible biologic links between diabetes and cancer risk, and 4) whether diabetes treatments influence risk of cancer or cancer prognosis. In addition, key unanswered questions for future research are posed.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/fe7951723b3caf62a81c35eba52784a58c0f3ffc

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In Endocrinology, Diabetes and Metabolism

In Molecular Biology

In Oncology

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Citations in the corpus

Standards of Medical Care in Diabetes—2013 (2012, background): “The association may result from shared risk factors between type 2 diabetes and cancer (obesity, age, and physical inactivity) but may also be due to hyperinsulinemia or hyperglycemia (401,403).”
Identification of type 2 diabetes subgroups through topological analysis of patient similarity (2015, background): “This pattern indicates that T2D can be either the risk factor for or consequence of many forms of cancer (56, 57).”
Shared Risk Factors in Cardiovascular Disease and Cancer (2016, background): “Despite some cancer types that notoriously strike during childhood, increasing age of ≥55 years is associated with 78% of the new cancer diagnoses in developed countries.(44)”
Standards of Medical Care in Diabetes—2014 (2013, background): “The association may result from shared risk factors between type 2 diabetes and cancer (obesity, age, physical inactivity) but may also be due to hyperinsulinemia or hyperglycemia (485,486).”
Metabolic Syndrome and Risk of Cancer (2012, background): “Preventive strategies (primary prevention and early detection of cancer) are urgently needed, as has been suggested for patients affected by fully developed diseases, such as diabetes (54).”
Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. (2012, background): “It has been associated with increased risk of several cancers [10].”
The impact of comorbidity on cancer and its treatment (2016, background): “In addition, some treatments for diabetes, particularly metformin and thiazolidinediones, appear to have antineoplastic activity, which may act to reduce cancer incidence and slow its progression.(56,57,60) Similarly, the use of nonsteroidal anti-inflammatory drugs used commonly in arthritis is asso”
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, background): “Mechanisms underlying the association of T2DM with cancer risk are as follows: firstly, T2DM and cancers usually share many risk factors such as age, obesity, sedentary lifestyle, smoking, higher intake of saturated fats and refined carbohydrates, and some psychology factors [85].”
Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association (2023, background): “12,13 However, the greatest clinical impact of CKM syndrome with regard to morbidity and premature mortality is through the disproportionate burden of CVD. 14 CKM syndrome affects vascular integrity, atherogenesis, myocardial function, hemostasis and cardiac conduction.”