Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
By C. Wolkow, Koutarou D. Kimura, M. Lee, Gary Ruvkun. Science, 2000
681 citations recorded by the source corpus.
Subfields: Aging, Endocrine and Autonomic Systems, Physiology
View Paper: https://www.semanticscholar.org/paper/fe2ee2858eb6a39a239bdc288a536e6b4b1d5e1c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
- C. Kenyon
- Richard I. Morimoto
- Norbert Perrimon
- Fabio Demontis
- James F Morley
- Nataliya Libina
- Jennifer R. Berman
- Cori Bargmann
In Endocrine and Autonomic Systems
- Richard I. Morimoto
- C. Kenyon
- Norbert Perrimon
- Fabio Demontis
- Nataliya Libina
- James F Morley
- Cori Bargmann
- V. Longo
In Physiology
- C. Kenyon
- Richard I. Morimoto
- Norbert Perrimon
- Fabio Demontis
- Cori Bargmann
- V. Longo
- Linda Partridge
- Mark P. Mattson
Citations in the corpus
- Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “…for muscle and neuronal cells are intriguing given previous observations that preservation of the nervous system is important in the regulation of longevity and that muscle cells of C. elegans are also particularly susceptible to aging-related decline (Wolkow et al., 2000; Herndon et al., 2002).”
- Insulin signaling promotes germline proliferation in C. elegans (2010, background): “The effect of IIR signaling on the germ line is separable from its effects on other processes The anatomical focus of activity for IIR signaling for dauer control is largely neuronal (Apfeld and Kenyon, 1998; Wolkow et al., 2000), whereas the anatomical focus for lifespan is predominantly intestinal”
- Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. (2004, neutral): “elegans nervous system has been shown to be sufficient for lifespan extension [40,41].”
- The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, neutral): “…of insulin/IGF-1 signaling (IIS) in neuronal or fat tissues (Broughton et al., 2005; Hwangbo et al., 2004; Kapahi et al., 2004; Libina et al., 2003; Wolkow et al., 2000); and genetic manipulations to specific neurons which then alter the capacity for the entire animal to respond to dietary…”
- Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. (2003, background): “The aging of C. elegans is controlled by an endodaf-2 mutants to control levels (Wolkow et al., 2000).”
- Chemosensation in C. elegans. (2006, background): “and many sensory neurons have a lifespan-regulatory role (Alcedo and Kenyon, 2004; Apfeld and Kenyon, 1999; Wolkow et al., 2000).”