Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level.

By R. Vieth, P. Chan, G. MacFarlane. American Journal of Clinical Nutrition, 2001

692 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/fdeecc32ecc47ec9cd3bfbf0e21ed0d3a2882a06

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Citations in the corpus

High prevalence of vitamin D inadequacy and implications for health. (2006, background): “245,246 Doses of 4000 IU/d for 3 months and 50,000 IU/wk for 2 months have been administered without toxicity.(11,247,248)”
Vitamin D in preventive medicine: are we ignoring the evidence? (2003, background): “Concentrations of 25(OH)D below 40– 50 nmol/l reflect vitamin D insufficiency (Malabanan et al. 1998, Need et al. 2000; Vieth et al. 2001b).”
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. (2010, background): “It reportedly takes ’3 mo to reach a steady state of vitamin D concentrations by supplementation (20).”
Vitamin D Supplementation during Pregnancy: Double Blind, Randomized Clinical Trial of Safety and Effectiveness (2011, methodology): “Our study was based on two previous vitamin D supplementation studies in nonpregnant adults that appeared to be safe.((48,58)) Prior to undertaking the NIH-funded study described here, however, we had to obtain an Investigational Drug Number from the FDA, which entailed writing a complete investigat”
Position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and athletic performance. (2009, background): “These athletes ould benefit from supplementation ith vitamin D at the Dietary Refernce Intake level (5 g/day or 200 IU or ages 19 to 49 years) (54,56,58-61).”
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. (2006, background): “88% of healthy young men and women to 75 nmol/L (133).”
Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial (2009, background): “concerns about the toxic effects of high doses of supplemental vitamin D have been allayed by safety and efficacy tests, which have demonstrated that doses of 100 and 250mg (4000 and 10 000 IU) per day for 5–6 months resulted in no toxic effects((16,17)).”