Measuring protein concentration with entangled photons
By Andrea Crespi, Mirko Lobino, Jonathan C. F. Matthews, Alberto Politi, C. Neal, Roberta Ramponi, Roberto Osellame, Jeremy Lloyd O'Brien. 2011
135 citations recorded by the source corpus.
Optical interferometry is amongst the most sensitive techniques for precision measurement. By increasing the light intensity, a more precise measurement can usually be made. However, if the sample is light sensitive entangled states can achieve the same precision with less exposure. This concept has been demonstrated in measurements of known optical components. Here, we use two-photon entangled states to measure the concentration of a blood protein in an aqueous buffer solution. We use an opto-fluidic device that couples a waveguide interferometer with a microfluidic channel. These results point the way to practical applications of quantum metrology to light-sensitive samples.
Subfields: Artificial Intelligence, Atomic and Molecular Physics, and Optics
View Paper: https://www.semanticscholar.org/paper/fdeb31e7c897c2cdd2e995a388474c487373f8e0
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In Artificial Intelligence
In Atomic and Molecular Physics, and Optics
Citations in the corpus
- Quantum metrology and its application in biology (2014, methodology): “PET. This enables a far broader range of applications. Entangled photon pairs have now been applied in tissue imaging [15], absorption imaging [14], and refractive index sensing of a protein solution [26]; squeezed states of light have been used both to measure dynamic changes [16] and image spatial”
- Spontaneous parametric down-conversion (2018, unknown): “One example was to use entangled photons for measuring protein concentration [41].”
- Biological measurement beyond the quantum limit (2012, background): “elations between photons which increase the capacity of each photon to extract information (6–8). Consequently, biology has long been viewed as an important frontier for quantum enhanced measurements (5,8,9). However, this quantum limit has never been surpassed in a biological measurement; this incl”