Quantum metrology and its application in biology
By Michael A. D. Taylor, Warwick P. Bowen. 2014
437 citations recorded by the source corpus.
Abstract Quantum metrology provides a route to overcome practical limits in sensing devices. It holds particular relevance to biology, where sensitivity and resolution constraints restrict applications both in fundamental biophysics and in medicine. Here, we review quantum metrology from this biological context, focusing on optical techniques due to their particular relevance for biological imaging, sensing, and stimulation. Our understanding of quantum mechanics has already enabled important applications in biology, including positron emission tomography (PET) with entangled photons, magnetic resonance imaging (MRI) using nuclear magnetic resonance, and bio-magnetic imaging with superconducting quantum interference devices (SQUIDs). In quantum metrology an even greater range of applications arise from the ability to not just understand, but to engineer, coherence and correlations at the quantum level. In the past few years, quite dramatic progress has been seen in applying these ideas into biological systems. Capabilities that have been demonstrated include enhanced sensitivity and resolution, immunity to imaging artefacts and technical noise, and characterization of the biological response to light at the single-photon level. New quantum measurement techniques offer even greater promise, raising the prospect for improved multi-photon microscopy and magnetic imaging, among many other possible applications. Realization of this potential will require cross-disciplinary input from researchers in both biology and quantum physics. In this review we seek to communicate the developments of quantum metrology in a way that is accessible to biologists and biophysicists, while providing sufficient details to allow the interested reader to obtain a solid understanding of the field. We further seek to introduce quantum physicists to some of the central challenges of optical measurements in biological science. We hope that this will aid in bridging the communication gap that exists between the fields, and thereby guide the future development of this multidisciplinary research area.
Subfields: Atomic and Molecular Physics, and Optics, Biophysics, Structural Biology
View Paper: https://www.semanticscholar.org/paper/8b39194b2d4d2aa0baaf49d77544ac38353146f0
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In Atomic and Molecular Physics, and Optics
- P. Moreau
- T. Gregory
- Warwick P. Bowen
- Miles J. Padgett
- E. Toninelli
- Marco G. Genoni
- Nicolas Treps
- K. Bliokh
In Biophysics
In Structural Biology
Citations in the corpus
- A perspective on multiparameter quantum metrology: From theoretical tools to applications in quantum imaging (2019, background): “Imaging stands out as the most informative and direct technique for inspecting biological systems [23, 24].”
- Imaging with quantum states of light (2019, background): “[100] M.”
- Advances in quantum imaging (2024, positive): “Bright squeezed light is ideally suited to overcome the photo-damage limit to SNR in imaging due to its compatibility with bright optical fields and its easy integration with standard imaging systems and detectors 39,41 .”