Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins

By Xunxian Liu, J. Rubin, A. Kimmel. 2005

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β-Catenin destruction complex: insights and questions from a structural perspective (2006, background): “A recent study has provided some evidence that Wnt signaling might both change the association of GSK3 with Axin and also the conformation of Axin (Liu et al., 2005).”
INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, unknown): “For example, Gαq and Gαo have been shown to dissociate the axin-GSK3β and axin2-GSK3β complex, respectively (Liu et al., 2005), and Gα12 and Gαs act on axin, which is the key negative regulator of the β-catenin-dependent WNT/FZD signalling pathway (Castellone et al., 2005; Stemmle et al., 2006).”
Wnt signaling: is the party in the nucleus? (2006, background): “Recent cell culture experiments further support the role for G proteins in the transduction of the Wnt signal from Fzd to -catenin (Liu et al. 2005).”