Gene silencing in cancer in association with promoter hypermethylation.

By J. Herman, S. Baylin. New England Journal of Medicine, 2003

3,472 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fd7603150d3240050285ae18283dfd1872c7fd0a

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In Molecular Biology

Citations in the corpus

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer (2005, background): “to the identification of genes that are transcriptionally silenced in cancer cells by CpG island promoter hypermethylatio”
Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non Small Cell Lung Cancer (2011, background): “Multiple levels of epigenetic silencing have been defined, among which two of the most fundamental are DNA methylation and chromatin deacetylation (3).”
The mitochondrial p53 pathway (2008, neutral): “However, many human cancers have lost this prerequisite due to global epigenetic deregulation of their genome, leading to broadly aberrant gene silencing patterns [45,46].”
Cancer epigenetics. (2005, background): “For the most part, cancer epigenetics has relied on measurements of CpG island DNA hypermethylation (7,60).”
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. (2010, background): “Hypermethylation of the MGMT promoter-associated CpG island has been shown in a large percentage of GBM patients (Esteller et al., 2000; Esteller et al., 1999; Hegi et al., 2005; Hegi et al., 2008; Herman and Baylin, 2003).”
MeInfoText: associated gene methylation and cancer information from text mining (2008, background): “The hypermethylation of CpG islands in gene promoter regions is associated with aberrant silencing of transcription and has been regarded as a common mechanism for inactivation of tumor suppressor genes in human cancer [3,6].”
MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data (2015, background): “Promoter DNA methylation for example influences gene expression, and aberrant methylation is found in almost every human cancer [5].”
Inflammation and necrosis promote tumour growth (2004, background): “, promote rounds of cell proliferation and death at the site of inflammation, which are often associated with hypermethylation of promoter regions in tumour-suppressor and/or pro-apoptotic gene”
DNA methylation and gene silencing in cancer (2005, background): “In cancer, EPIGENETIC SILENCING through methylation occurs at least as frequently as mutations or deletions and leads to aberrant silencing of normal tumor-suppressor function”
High-throughput DNA methylation profiling using universal bead arrays. (2006, background): “Hypermethylation of CpG islands located in the promoter regions of tumor suppressor genes is now firmly established as the most frequent mechanism for gene inactivation in cancers (Esteller 2002; Herman and Baylin 2003).”