Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
By E. Porrello, A. Mahmoud, E. Simpson, Brett A. Johnson, D. Grinsfelder, Diana C. Canseco, P. Mammen, B. Rothermel, E. Olson, Hesham A. Sadek. Proceedings of the National Academy of Sciences of the United States of America, 2012
738 citations recorded by the source corpus.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/fd2d43b9536b42c2b39bdeddb877dd0b1db31492
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In Molecular Biology
- E. Olson
- Nikolaos G. Frangogiannis
- J. Richardson
- R. Bassel-Duby
- X. Qi
- L. Sutherland
- Douglas L. Mann
- D. Ornitz
In Surgery
Citations in the corpus
- Pathophysiology of Myocardial Infarction (2015, positive): “Recent studies have suggested that neonatal mice can regenerate the heart following apical resection (291), or coronary ligation (292).”
- The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, positive): “However, this regenerative capacity is lost by postnatal day 7 (Porrello et al., 2011b, 2013), which coincides with cardiomyocyte binucleation and cell-cycle arrest (Soonpaa et al., 1996).”
- Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart (2014, result): “Consistent with previous studies reporting age-related reduction in the ability to regenerate myocardium after apical resection or coronary artery ligation (10, 11, 13), postnatal day 1 (P1) mice demonstrated minimal mortality after either one or three DT injections.”
- Hippo pathway effector Yap promotes cardiac regeneration (2013, methodology): “Discussion Although the neonatal mouse heart displays a remarkable ability to regenerate after injury (13, 14), this regenerative potential is lost during the first week of life, such that injury thereafter results in loss of cardiomyocytes, fibrosis, and diminished pump function.”