A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions

By P. Marambaud, J. Shioi, G. Serban, A. Georgakopoulos, S. Sarner, V. Nagy, L. Baki, P. Wen, S. Efthimiopoulos, Zhiping Shao and 2 more. EMBO Journal, 2002

693 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fd26b668757c1d2dc2bffd863ec03009a8e09d97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Gerhard Christofori
2. Mahmut Yilmaz
3. R. Weinberg
4. D. Hanahan

In Molecular Biology

1. Mahmut Yilmaz
2. Jiri Zavadil
3. Erwin P. Bottinger
4. Albert B. Reynolds
5. Gerhard Christofori
6. Michael A. Davis
7. R. Ireton
8. R. Weinberg

Citations in the corpus

• Upregulated function of mitochondria-associated ER membranes in Alzheimer disease (2012, neutral): “…numerous sub-cellular compartments, including endoplasmic reticulum (ER) (Annaert et al , 1999), Golgi (Annaert et al , 1999), plasma membrane (PM) (Marambaud et al , 2002), nuclear envelope (Kimura et al , 2001), endosomes (Vetrivel et al , 2004), lysosomes (Pasternak et al , 2003), and…”
• EMT, the cytoskeleton, and cancer cell invasion (2009, background): “On the post-translational level, the transport of newly synthesized E-cadherin to the cell membrane can be inhibited via O-glycolysation [51] or mature, membranebound E-cadherin can be degraded by proteolytic cleavage or endocytosed from the plasma membrane [52–55].”
• A core function for p120-catenin in cadherin turnover (2003, background): “Presenilin-1 binding promotes proteolytic degradation of E-cadherin (Baki et al., 2001; Marambaud et al., 2002), whereas Hakai is a ubiquitin ligase that binds tyrosine-phosphorylated E-cadherin, leading to its ubiquitination and destruction (Fujita et al., 2002).”