Validating novel tau PET tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

By Marta Marquié, M. Normandin, C. Vanderburg, Isabel Costantino, Elizabeth A Bien, Lisa G Rycyna, William E. Klunk, Chester A. Mathis, M. Ikonomovic, M. Debnath and 8 more. Annals of Neurology, 2015

615 citations recorded by the source corpus.

To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament‐tau–containing lesions, and to determine whether there is off‐target binding to other amyloid/non‐amyloid proteins.

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Citations in the corpus

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease (2017, background): “Furthermore, as regions that are likely to reflect extensive offtarget binding, we excluded basal ganglia (Lowe et al., 2016; Marquié et al., 2015) and thalamus from the Braak ROIs.”
A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers (2016, background): “Tau PET is being actively investigated, but initial data indicate that tau PET ligands have high binding affinity for paired helical filament tau in AD but have much weaker affinity in non-AD tauopathies, especially those with straight filament tangles.(9) Atrophy and hypometabolism involving AD-lik”
PET Imaging of Tau Deposition in the Aging Human Brain (2016, unknown): “Post-mortem tissue studies provided evidence that AV-1451 binds selectively to PHF tau but not Ab or other common protein aggregates (Marquie et al., 2015; Xia et al., 2013).”
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. (2016, unknown): “…at t = 80–100 minutes post-injection were created by normalizing summed activity from the realigned frames to mean activity in cerebellar grey matter, an area relatively spared of neurofibrillary tangle pathology even in advanced Alzheimer’s disease (Braak and Braak, 1991; Marquie et al., 2015).”