Metabolic origins and clinical significance of LDL heterogeneity DOI 10.1194/jlr.R200004-JLR200

By K. Berneis, Ronald M. Krauss. Journal of Lipid Research, 2002

885 citations recorded by the source corpus.

LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL. Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease.

Subfields: Endocrinology, Diabetes and Metabolism, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/fccd22982525545cc1a4929ab94a34f276c2ee78

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

In Physiology

In Surgery

Citations in the corpus

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “be influenced by the proteome, lipidome, proteoglycan binding, aggregability, and oxidative susceptibility.(64,96,97) The atherogenic”
The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation (2020, background): “decrease of its size, and acquisition of negative charge [28].”
Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “[81] Berneis KK, Krauss RM.”
Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. (2007, neutral): “(%)‡ 22 (29) 20 (25) 29 (37) 27 (36) 99 (32)”
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus (2010, positive): “The full Methods provides information about all experimental procedures: (1) description of association analyses in the population cohorts; (2) description of genotype-expression analyses in human liver, subcutaneous adipose, and omental adipose samples; (3) details for generation of luciferase expr”