Gut hormone PYY3-36 physiologically inhibits food intake

By R. Batterham, M. Cowley, C. Small, H. Herzog, Mark A Cohen, C. Dakin, A. Wren, A. Brynes, M. Low, M. Ghatei and 2 more. Nature, 2002

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The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, methodology): “In short, mouse ghrelin genomic DNA m hypothalamic slices as previously described (Cowley et al., 2001; clones were isolated from Lambda KOS genomic library using exon- Heisler et al., 2002; Batterham et al., 2002).”
Gut hormones and the regulation of energy homeostasis (2006, background): “Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.”
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “[30] Batterham RL, Cowley MA, Small CJ, et al.”
Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Prospective, Double Blind Study (2008, background): “It is released postprandially from the distal gastrointestinal tract and it acts within the arcuate nucleus to inhibit the release of neuropeptide Y.(19) Intravenous infusion of PYY3–36 in humans induces satiety and reduces food intake.”