Unveiling the role of network and systems biology in drug discovery.

By Albert Pujol, Roberto Mosca, J. Farrés, Patrick Aloy. TIPS - Trends in Pharmacological Sciences, 2010

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The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored (2010, background): “Indeed, the ‘network view’ on a genome is increasingly being taken in many areas of applied biology: protein networks are used to increase the statistical power in human genetics (1,2), to aid in drug discovery (3,4), to close gaps in metabolic enzyme knowledge (5,6) and to predict phenotypes and ge”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “Drug combinations and multitarget drugs develop less resistance (Zimmermann et al., 2007; Pujol et al., 2010; Rosado et al., 2011; Savino et al., 2012).”