Cholesterol, inflammation and innate immunity

By A. Tall, L. Yvan-Charvet. Nature reviews. Immunology, 2015

1,349 citations recorded by the source corpus.

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other immune cells, which promotes inflammatory responses, including augmentation of Toll-like receptor (TLR) signalling, inflammasome activation, and the production of monocytes and neutrophils in the bone marrow and spleen. On a cellular level, activation of TLR signalling leads to decreased cholesterol efflux, which results in further cholesterol accumulation and the amplification of inflammatory responses. Although cholesterol accumulation through the promotion of inflammatory responses probably has beneficial effects in the response to infections, it worsens diseases that are associated with chronic metabolic inflammation, including atherosclerosis and obesity. Therapeutic interventions such as increased production or infusion of high-density lipoproteins may sever the links between cholesterol accumulation and inflammation, and have beneficial effects in patients with metabolic diseases.

Subfields: Epidemiology, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/fcae6609fdff81782747b68c169274935db7c412

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In Epidemiology

1. Klaus Ley
2. D. Wolf
3. E. Latz

In Immunology

1. Klaus Ley
2. D. Wolf
3. A. Grebe
4. E. Latz
5. Florian Hoss

In Surgery

1. Klaus Ley
2. D. Wolf

Citations in the corpus

• Immunity and Inflammation in atherosclerosis (2019, background): “Notably, attenuating cholesterol storage and enhancing cholesterol efflux pathways may favor the resolution of plaque inflammation and even promote plaque regression.(23) The myeloid response is accompanied by the infiltration of cells of the adaptive immune system, B and T cells.”
• NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. (2018, background): “However, it turned out that cholesterol and inflammation are interconnected, because cellular cholesterol accumulation promotes inflammatory responses, whereas immune cell activation promotes cholesterol accumulation by impairing cellular cholesterol efflux.(29) Although the mechanisms driving the s”