Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial.

By P. Sheehan, Peter Jones, J. Giurini, A. Caselli, A. Veves. Plastic and Reconstructive Surgery, 2003

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The humanistic and economic burden of chronic wounds: A systematic review (2018, background): “Wounds that failed to heal within 3 weeks were considered chronic, as ulcers not reducing in size after 4 weeks are probable to become chronic.(13) As there is no preestablished consensus for chronicity and when a wound generally is considered as chronic a duration of ≥3 weeks was deemed appropriate”
Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights (2014, background): “usually ulcers that fail to heal after a 12-week period are characterized as chronic [17].”
Challenges in the Treatment of Chronic Wounds (2015, background): “published the often quoted article supporting the ability of the 4-week healing rate to predict complete healing by 12 weeks.(111) Using data from another large, multicenter randomized controlled trial (RCT), it was determined that the midpoint (median) percent wound area reduction from baseline at ”