DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

By M. R. Rountree, K. Bachman, S. Baylin. Nature Genetics, 2000

1,117 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fc4a3b7d7a319a86f0e271612f52dee93724040a

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Citations in the corpus

Epigenetic Determinants of Cancer. (2016, background): “This protein loss is potentially very important for the DNMT inhibitors to achieve reexpression of key cancer genes because, experimentally, all three biologically active DNMTs can exert transcriptional repression independent of catalyzing DNA methylation (Fuks et al. 2000; Robertson et al. 2000; Ro”
Developmental regulation of DNA replication timing at the human β globin locus (2001, background): “with late replication foci (Rountree et al., 2000) strongly support this concept.”
Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans (2004, methodology): “for nucleosomal HAT activity, full-length Tip60, Tip60b, ING3, ING3(1-300),”
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. (2002, background): “, may be maintained by enzymes that accompany DNA 1970; Ahmad and Henikoff, 2001); thus all mitotic figures in these replication machinery (Rountree et al., 2000), it appears preparations are from cells that were induced after S phase was that lysine methylation is irreversible (Jenuwein, 2001).”
DNA methylation, methyltransferases, and cancer (2001, background): “Furthermore, MBD2, HDAC1, HDAC2, and RbAp46/ 48 co-purify in HeLa cell nuclear extracts and are components of the MeCP1 repressor complex (Ng et al., 1999).”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, background): “Also, all the DNMTs assuredly participate in complex protein interactions where they may exert scaffolding functions with effects on other chromatin regulatory features (Robertson et al., 2000; Rountree et al., 2000).”
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer (2002, background): “5 uk AA457731 SNARE protein YKT6 6 uk AA419251 interferon induced transmembrane protein 1 (9-27) IFITM1 11 uk N48178 KIAA0403 protein 6 uk AA027147 hypothetical protein MGC3040 3 uk H18646 hypothetical protein FLJ10697 10 uk AA013268 Homo sapiens mRNA containing (CAG)4 repeat, clone CZ-CAG-7 UK uk A”
Chromatin challenges during DNA replication and repair. (2007, neutral): “DNMT1 interacts with HDACs (Fuks et al., 2000; Rountree et al., 2000), the ATP-dependent chromatin-remodeling enzyme SNF2h (Rob-ertson et al., 2004), the polycomb protein EZH2 that directs H3K27me (Vire et al., 2006), and the H3K9 methyl-transferase G9a (Esteve et al., 2006).”