High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.

By A. Oliver, R. Cantón, P. Campo, F. Baquero, J. Blázquez. Science, 2000

1,570 citations recorded by the source corpus.

Subfields: Genetics, Molecular Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/fc495d73baf15f79fd58c596cd47b9322502b489

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In Genetics

In Molecular Medicine

In Pulmonary and Respiratory Medicine

Citations in the corpus

Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. (2011, background): “Long-term exposure of isolates in the CF lung to antibiotics leads to the accumulation of mutations that confer highly complex phenotypes in strains with defective mismatch repair systems (Oliver et al., 2000).”
Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections (2016, background): “Other adaptations include the accumulation of auxotrophic mutations in the amino acid-rich lung environment [15], loss of motility [16], and the emergence of hypermutators [17], which display elevated mutation rates due to defects in DNA repair mechanisms.”
Bacterial resistance: origins, epidemiology, and impact. (2003, background): “[19] found that 36% of 30 chronically colonized”
The role of DNA mismatch repair and oxidative DNA damage defense systems in avoidance of stationary phase mutations in Pseudomonas putida (2007, background): “coli DNA polymerases act coordinately with their associated accessory factors in the context of DNA replication, repair, and recombination (60).”
Micro- and macrorheology of mucus (2009, neutral): “Nonetheless, if mucus becomes sufficiently thick to disable mucociliary transport in the lung, the blocked flow actually leads to bacterial overgrowth and infections, a primary complication found in cystic fibrosis patients [122,123].”
Pseudomonas genomes: diverse and adaptable. (2011, background): “…themselves in a number of ways, including the emergence of colony morphology variants (Govan & Deretic, 1996; Haussler et al., 2003), hypermutability (Oliver et al., 2000) and diversity in both antimicrobial susceptibility and virulence traits (von Gotz et al., 2004; Fothergill et al., 2007).”
Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. (2016, background): “tator strains (Oliver et al. 2000) that contribute to selection of mucoid variants (Oliver et al.”
Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World? (2013, background): “aeruginosa develop resistance to antipseudomonal antimicrobials much more frequently than nonmutators (353, 358), with efficient development of resistance through chromosomal mutation (359).”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “However, hypermutators also display other phenotypes such as mucoidity, lack of motility and LPS production (Oliver et al., 2000; Ciofu et al., 2010; Varga et al., 2015).”